PTU-055 Long-Term Efficacy of Adalimumab for Treatment of Moderately to Severely Active Ulcerative Colitis
نویسندگان
چکیده
منابع مشابه
Understanding the Role of Adalimumab in the Treatment of Moderately to Severely Active Ulcerative Colitis
Ulcerative colitis (UC) is a chronic inflammatory colonic disease with repetitive episodes of remission and relapse. Although the precise etiology of UC remains unclear, interactions between the immune system and the environment and, in particular, interactions between the genetic make-up and gut microbiota are considered to be the main factors responsible for UC development. Recently, the ther...
متن کاملAdalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial.
OBJECTIVE The aim of this study was to assess the efficacy and safety of adalimumab (ADA), a recombinant human monoclonal antibody against tumour necrosis factor α (TNF), for the induction of clinical remission in anti-TNF naïve patients with moderately to severely active ulcerative colitis. METHODS This 8-week, multicentre, randomised, double-blind, placebo-controlled study (NCT00385736), co...
متن کاملSystematic Review with Network Meta-Analysis: Comparative Efficacy of Biologics in the Treatment of Moderately to Severely Active Ulcerative Colitis
BACKGROUND Biological therapies are increasingly used to treat ulcerative colitis (UC). AIM To compare the efficacy of biologics in adults with moderately-to-severely active UC, stratified by prior exposure to anti-tumour necrosis factor (anti-TNF) therapy. METHODS A systematic literature review was undertaken to identify studies of biologics approved for UC. Network meta-analysis was condu...
متن کاملEfficacy and Safety of Adalimumab in Moderately to Severely Active Cases of Ulcerative Colitis: A Meta-Analysis of Published Placebo-Controlled Trials
BACKGROUND/AIMS To evaluate the efficacy and safety of adalimumab (ADA) in moderately to severely active ulcerative colitis (UC) patients who are unresponsive to traditional therapy. METHODS Electronic databases, including the PubMed, Embase, and Cochrane databases, were searched to April 20, 2014. UC-related randomized controlled trials (RCTs) that compared ADA with placebo were eligible. Re...
متن کاملBiological agents for moderately to severely active ulcerative colitis: a systematic review and network meta-analysis.
BACKGROUND Biological agents are emerging treatment options for the management of ulcerative colitis (UC). PURPOSE To assess the comparative efficacy and harm of biological agents in adult patients with moderately to severely active UC who are naive to biological agents. DATA SOURCES MEDLINE, EMBASE, and Cochrane Library from inception through December 2013, without language restrictions, a...
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ژورنال
عنوان ژورنال: Gut
سال: 2013
ISSN: 0017-5749,1468-3288
DOI: 10.1136/gutjnl-2013-304907.147